Research & Inventions
Building the instruments, writing the protocols.
A patent portfolio, a biotechnology venture, and a body of clinical research focused on making implant surgery more precise and sleep apnea therapy more predictable.
APP-NEA, LLC
Augmented
intelligence.
Biotechnology
Predicting oral appliance response in sleep apnea.
APP-NEA is a healthcare biotechnology firm where Dr. Singh serves as CEO and chief scientific officer. The company applies deep learning to a clinical question that has resisted clean answers for decades: which patients with obstructive sleep apnea will respond to oral appliance therapy, and which will not.
The work draws on three streams of data — polysomnography, cone-beam imaging of the airway, and longitudinal outcomes from titrated mandibular advancement devices — with the aim of producing a predictive algorithm that clinicians can use before a device is ever fabricated.
Patents · Meisinger
Guided precision surgery.
Dr. Singh invented the minimally invasive guided implant and harvesting system produced commercially by Meisinger, now in use worldwide for dental implant placement, autogenous bone and soft-tissue harvesting, and regenerative procedures.
The system — the GPS Trephine family of instruments — is the practical expression of a longer thesis in his published work: that the precision of computer planning is only as useful as the instruments that execute it at the chair.
GPS
Research focus
Ongoing lines of inquiry.
Computer-planned and guided implant surgery
Reducing surgical risk and improving prosthetic predictability through 3D-imaging-driven workflows.
Autologous platelet concentrates
PRGF and PRP as additives in bone grafting and soft-tissue augmentation.
Mandibular advancement vs CPAP
Comparative outcomes in moderate-to-severe obstructive sleep apnea.
Neurovascular preservation
Translocation and repair of the inferior alveolar, mental, and palatine bundles during implant placement.
Sleep, cognition, and cardiovascular risk
Associations between nonrestorative sleep, OSA, and major adverse cardiac and cerebrovascular events.
Augmented intelligence in dentistry
Predictive modeling for oral appliance response and individualized titration.